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(NAD+ & SIRT1?) - If you are going to live countless years: THE ARTERIES healed and reversed here!

Investigators at Harvard Medical School have identified the key cellular mechanisms behind vascular aging and its effects on muscle health, ...

Tuesday, June 10, 2014

Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression.

Epidemiological and experimental studies indicate that early vascular dysfunction occurs in low-birth-weight subjects, especially preterm (PT) infants. We recently reported impaired angiogenic activity of endothelial colony-forming cells (ECFCs) in this condition. We hypothesized that ECFC dysfunction in PT might result from premature senescence and investigated the underlying mechanisms. Compared with ECFCs from term neonates (n = 18), ECFCs isolated from PT (n = 29) display an accelerated senescence sustained by growth arrest and increased senescence-associated β-galactosidase activity. Increased p16(INK4a) expression, in the absence of telomere shortening, indicates that premature PT-ECFC aging results from stress-induced senescence. SIRT1 level, a nicotinamide adenine dinucleotide-dependent deacetylase with anti-aging activities, is dramatically decreased in PT-ECFCs and correlated with gestational age. SIRT1 deficiency is subsequent to epigenetic silencing of its promoter. Transient SIRT1 overexpression or chemical induction by resveratrol treatment reverses senescence phenotype, and rescues in vitro PT-ECFC angiogenic defect in a SIRT1-dependent manner. SIRT1 overexpression also restores PT-ECFC capacity for neovessel formation in vivo. We thus demonstrate that decreased expression of SIRT1 drives accelerated senescence of PT-ECFCs, and acts as a critical determinant of the PT-ECFC angiogenic defect. These findings lay new grounds for understanding the increased cardiovascular risk in individuals born prematurely and open perspectives for therapeutic strategy.
http://www.ncbi.nlm.nih.gov/pubmed/24518759

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DREAMNOTES:

Dream: Cancer Caused By the Presence of 3; 1 Halugenic, Invent Control 7 for Halugenic - "rinig" (Listen/Hear) Genome, Water
 
Dream:"If half the world are women, how can we solve the problem without a woman?"
 
Dream: "Regenerate Young" & "Genetic Cycling"
 
Dream: `You Need to Add Resources`
 
Dream: [Billions will be poured into (Biomedical Gerontology) once they find out that a cure is possible]
 
Dream: "Usually you need some kind of pill that can end on those numbers"
 
Dream: "Metformin Reverses Aging" [And I saw a human alien, they look pale white, countless years old head abacked popping a pill"
 
Dream: "Goat's Ruin"
 
Dream: Take [Metformin] Twice a Day
 
Dream: "There is no better version than SIRT1"
 
Dream: "Watermelon Husks"
 
Dream: "Oral Sex after giving birth may lead to cancer"
 
Dream: "Do you have a problem with Science in the non-adoption of protected articles"
 
Dream: IT;S ENZYMES BASED
 
Dream: Mustard [curcumin/turmeric], study it, cancer
 
Dream: "Not Semination, Fertilization but less than 50% fat/around cell & 30% Fatty Liver"
 
Dream: "Have to Add curcumin to something else"
 
Dream: [I decided to ask for cure for cancer they said VINEGAR but not for all cancers, new cancers given to our Earth intentionally not cured yet]
 
Dream: "Need Grape to Escape"
 
Dream: [I saw an ancient dead person depicting instead of the body part which had gotten cancer, the cancer was first in the arteries]
 
Dream: "Blue Light"
 
Dream: of Dreamt Notes my cancer growth from NASA / shrunk Treated w' PH 7
 
Dream: Started in Intestines [Porcelain w' spots not smooth] "HOLD IT UP UNDER THE LIGHT"
 
Dream: saw Guyana Berry ? (10/25/2011 morning)
 
Dream: Reading a book ..is to assume [falsely] two cancer cells are moving in parenthesis saying by Jesus
 
Dream: when reversing Somatic Stem Cell must stop well before becomes erratic
 
Dream: instead of fire causing power which bad plants still around & spread, key was icing power (better) which turned to melted water/drained out
 
Dream: about doctor talking resistance like saying dont drink alot alcohol like some
 
Dream: Man surviving climate changes, up to neck in water, time slip, bird feet drops off man again; now, need man cries "Honey" to live on... (for good)
 
Dream: have had dreams "Crustaceans"
 
Dream: I was drinking from a 3rd water, head straight back, upwards drinking from dripping 3rd water then saw Daphne (from Scooby Doo)
 
Dream: I saw a pale white middle aged human alien countless years old showing me popping back a metformin pill
 
Dream: Saw face of Aubrey De Grey getting younger
 
Dream: [saw hot dog in bun] cure for cancer is ketchup & mustard
 
New Dream: Stemcells - When you choose the sex it dies off; only "Nature Living Stem Cells"
 
New Dream: Cancer change fish oil
 
New Dream: "Biological Immunity"
 

Dream: Sun Sweet Tomatoes (only)

Dream: Sun Sweet Tomatoes (only)
Me/mentioned once on TV: There is no time "[eat] 3X a Week"

SIRT1 is necessary for telomere elongation and for genome integrity during cell reprogramming

KEY= Protein: Active regulator of SIRT1 / Organism: Daphnia Magna

Does Citrulline Sit at the Nexus of Metformin’s Pleotropic Effects on Metabolism

(after, also dream post-approved finding= "..but IF IT WASN'T FOR THE #ANTIBODY")

Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway.
 
https://www.ncbi.nlm.nih.gov/pubmed/23071533

God put a shaky barrier when reversing Somatic Stem Cell past it you don't get the same thing