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Tuesday, June 10, 2014
Sirt1: Secret to healthy ageing unlocked!
New York, June 10 (IANS) Ageing is inevitable, but the secret to why some people age more gracefully could lie in the functioning of a protein in our body. Sirtuin1 (SIRT1) protein could be the key to maintain the health of ageing blood stem cells as loss of this protein affects their ability to regenerate blood normally, a study indicates. "Our data shows that SIRT1 is a protein that is required to maintain the health of blood stem cells and supports the possibility that reduced function of this protein with age may compromise healthy ageing," explained Saghi Ghaffari, an associate professor at Icahn School of Medicine at Mount Sinai Hospital in New York City. Humans store stem cell pools in key tissues, including blood. These stem cells can become replacement cells for those lost to wear and tear. But as the blood stem cells age, their ability to regenerate blood declines, potentially contributing to anaemia and the risk of cancers like acute myeloid leukemia and immune deficiency. The new study showed that young blood stem cells that lack SIRT1 behave like old ones. With use of advanced mouse models, the researchers found that blood stem cells without adequate SIRT1 resembled aged and defective stem cells, which are thought to be linked to development of malignancies. "The notion that SIRT1 is a powerful regulator of ageing has been highly debated, but its connection to the health of blood stem cells is now clear," Ghaffari added. "Identifying regulators of stem cell ageing is of major significance for public health because of their potential power to promote healthy ageing and provide targets to combat diseases of ageing," she noted. The findings appeared in the journal Stem Cell Reports.
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Proud to announce the release of the Encyclopedia of Biomedical Gerontology, edited by professor Suresh Rattan. #gerontology, #aginghttps://t.co/fLsaMqQJxW
Go Daphnia! Does genome size matter? this water flea has 8000 more genes than human http://bit.ly/hYpD2H #genome— Juliana A (@Symbiologica) February 4, 2011
In 1900 the average lifespan in the US was 47.— Quirky Facts (@QuirkFacts) February 22, 2015
Regardless whether you put #aging out of your mind or not you're going to continue to age until it becomes a problem. Instead of putting it out of your mind until the problem's at your doorstep why not try to reverse it? Indeed biogerontology & biomedical gerontology are on it.— Zena O'Brien #GeneralStrike (@ZenaMOBrien) January 10, 2019
pic.twitter.com/KHwpVKfIt9— Elsevier Major Reference Works (@ElsevierMRW) December 9, 2019
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