So AMPK/Sirt1 likely promote each other's activation (which is why teasing out MOA, determining true cause and effect can be hard)
— Joshua Samsoondar (@jsamsoondar) July 4, 2018
Further complicating things is timing, duration, dosing, etc. ie in this paper chronic metformin increases murine Sirt1 https://t.co/30vioi25ZF 8/ pic.twitter.com/rufhVQMSXp
According to the researchers, metformin works on the ‘longevity gene’ SIRT1 to protect the user’s vascular system against deterioration caused by glucose toxicity.